PLAG1

Across TCGA patient cohorts, PLAG1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLAG1-associated genes across cancer lineages are HER2, PDCD4, and Shc_pY317. Each is linked with PLAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAG1-to-partner and partner-to-PLAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER2 grouped by PLAG1-low versus PLAG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAG1→partner) and Y-score (partner→PLAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER2 →	+0.322	+1.514	.014	.014	3	2
UCEC	PDCD4 →	-0.469	-2.321	<.001	.005	3	2
UCEC	Shc_pY317 →	-0.180	-1.485	<.001	.003	3	2
UCEC	Smad3 →	+0.101	+1.514	.020	.014	3	2
UCEC	STAT3_pY705 →	-0.384	-1.688	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.087	-1.973	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

HER2 by PLAG1 expression — UCEC

Explore this box plot interactively →