PLAG1

Across TCGA cell cohorts, PLAG1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PLAG1-associated genes across cancer lineages are TGM6, TEX43, and OOSP4B. Each is linked with PLAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAG1-to-partner and partner-to-PLAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGM6 grouped by PLAG1-low versus PLAG1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAG1→partner) and Y-score (partner→PLAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TGM6 →	+0.022	+5.569	<.001	.001	3	1
BREAST	TEX43 →	+0.182	+4.672	<.001	.002	3	1
BREAST	OOSP4B →	+0.030	+4.781	<.001	.003	3	1
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1
BLOOD_Leukemia	MYPN →	+0.037	+4.152	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TGM6 by PLAG1 expression — BLOOD_Leukemia

Explore this box plot interactively →