PLAC4

Across TCGA pan-cancer cohorts, PLAC4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PLAC4 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PLAC4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PLAC4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LIHC show a favorable association.

ACC, COAD, and HNSC are the cancer types where PLAC4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.731	0.951	.003	54	view →
COAD	OS	Median	III,IV	0.542	0.839	<.001	47	view →
HNSC	DFS	Median	All	0.741	0.648	.007	43	view →
UVM	DFS	Median	All	0.261	0.681	.002	33	view →
KIRC	DFS	Quartile	All	0.450	0.728	.003	29	view →
OV	OS	Tertile	IV	0.650	0.888	.008	24	view →
THCA	DFS	Tertile	II,III,IV	0.458	0.830	.008	22	view →
LIHC	DFS	Tertile	III,IV	0.637	0.257	.003	21	view →
LGG	DFS	Tertile	All	0.730	0.863	.004	21	view →
CHOL	DFS	Tertile	All	0.712	0.221	.004	18	view →
UCEC	DFS	Tertile	All	0.874	0.794	.028	16	view →
UCS	OS	Median	II,III,IV	0.214	0.556	.015	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PLAC4–ACC (OS)

Open the ACC breakdown →