PLAC1

Across TCGA patient cohorts, PLAC1 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLAC1-associated genes across cancer lineages are RNU6-262P, RNA5SP113, and STAU2P1. Each is linked with PLAC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAC1-to-partner and partner-to-PLAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-262P grouped by PLAC1-low versus PLAC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAC1→partner) and Y-score (partner→PLAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-262P →	+0.636	+3.525	<.001	.008	3	2
UCEC	RNA5SP113 →	+0.716	+4.226	<.001	.008	3	2
UCEC	STAU2P1 →	+0.260	+3.760	.001	.006	3	2
CESC	RN7SL813P →	+0.225	+5.103	<.001	.008	3	1
CESC	SLC25A5P9 →	+0.055	+5.418	<.001	.005	3	1
CESC	RNU6-1191P →	+0.803	+5.103	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

RNU6-262P by PLAC1 expression — UCEC

Explore this box plot interactively →