PLAAT3

Across TCGA pan-cancer cohorts, PLAAT3 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PLAAT3 data layer compared with 22 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PLAAT3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PLAAT3 expression acts as an unfavorable survival marker.

SKCM and UCEC are the cancer types where PLAAT3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.214	0.708	<.001	28	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PLAAT3–SKCM (OS)

Open the SKCM breakdown →