PLAAT1

Across TCGA patient cohorts, PLAAT1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLAAT1-associated genes across cancer lineages are A-Raf_pS299, JNK_pT183_Y185, and N-Ras. Each is linked with PLAAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAAT1-to-partner and partner-to-PLAAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PLAAT1-low versus PLAAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAAT1→partner) and Y-score (partner→PLAAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.160	-3.169	.005	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.174	-2.446	.033	.020	3	1
UCEC	N-Ras →	-0.153	-2.980	.007	.036	3	1
UCEC	p62 Lck ligand →	+0.462	+3.584	.003	.002	3	1
UCEC	Akt_pT308 →	+0.745	+2.999	.014	.035	3	1
UCEC	PRAS40_pT246 →	+0.214	+3.000	.009	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

A-Raf_pS299 by PLAAT1 expression — UCEC

Explore this box plot interactively →