PLAAT1

Across TCGA cell cohorts, PLAAT1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLAAT1-associated genes across cancer lineages are REG1B, OR10AG1, and C6orf118. Each is linked with PLAAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLAAT1-to-partner and partner-to-PLAAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by PLAAT1-low versus PLAAT1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLAAT1→partner) and Y-score (partner→PLAAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	1
BREAST	OR10AG1 →	+0.013	+5.169	<.001	.005	3	1
LARGE_INTESTINE	C6orf118 →	+0.203	+3.793	<.001	.007	3	1
LARGE_INTESTINE	GZMK →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	HOXB1 →	+0.024	+3.791	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

REG1B by PLAAT1 expression — BREAST

Explore this box plot interactively →