PLAA

Across TCGA pan-cancer cohorts, PLAA mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PLAA’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PLAA mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PLAA is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

COAD, LUAD, and PDAC are the cancer types where PLAA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLAA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+0.134	<.001	7	view →
LUAD	Male	All	+0.160	<.001	5	view →
PDAC	All	All	−0.142	.002	4	view →
HNSC	All	All	+0.121	.017	4	view →
LSCC	Male	All	+0.161	<.001	3	view →
OV	All	All	+0.249	.015	2	view →
CCRCC	All	All	−0.065	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PLAA–COAD

Open the COAD breakdown →