PLA2G7

Across TCGA patient cohorts, PLA2G7 mutation is significantly associated with the RNA expression of many other genes, with 3,371 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G7-associated genes across cancer lineages are RNU6-5P, RNU6-271P, and LAS1L. Each is linked with PLA2G7 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLA2G7-to-partner and partner-to-PLA2G7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-5P grouped by PLA2G7-low versus PLA2G7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G7→partner) and Y-score (partner→PLA2G7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-5P →	+0.638	+4.068	.002	.001	3	3
UCEC	RNU6-271P →	+0.212	+2.764	<.001	.003	3	3
UCEC	LAS1L →	+0.375	+3.269	.001	<.001	3	2
UCEC	PWWP3A →	+0.520	+3.628	<.001	.001	3	2
UCEC	SAP30 →	+0.755	+2.955	<.001	<.001	3	2
UCEC	NDUFS4 →	+0.556	+2.098	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,371 associations by consensus.

RNU6-5P by PLA2G7 expression — COAD

Explore this box plot interactively →