PLA2G7

Across TCGA patient cohorts, PLA2G7 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G7-associated genes across cancer lineages are EGFR_pY1068, PDCD4, and PKC-b-II_pS660. Each is linked with PLA2G7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G7-to-partner and partner-to-PLA2G7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PLA2G7-low versus PLA2G7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G7→partner) and Y-score (partner→PLA2G7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.335	-3.169	<.001	<.001	3	2
UCEC	PDCD4 →	-0.692	-2.797	<.001	.003	3	2
UCEC	PKC-b-II_pS660 →	-0.227	-2.000	.037	.010	3	2
UCEC	Shc_pY317 →	-0.214	-3.459	<.001	.005	3	2
UCEC	eIF4E →	+0.164	+2.459	.047	.019	2	2
UCEC	A-Raf_pS299 →	-0.117	-2.459	.012	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

EGFR_pY1068 by PLA2G7 expression — UCEC

Explore this box plot interactively →