PLA2G7

Across TCGA cell cohorts, PLA2G7 mutation is significantly associated with the drug of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLA2G7-associated genes across cancer lineages are AT-7519, WYE-125132, and MetAP2 Inhibitor. Each is linked with PLA2G7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G7-to-partner and partner-to-PLA2G7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AT-7519 grouped by PLA2G7-low versus PLA2G7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G7→partner) and Y-score (partner→PLA2G7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AT-7519 →	+0.903	+2.807	.011	.044	3	1
LARGE_INTESTINE	WYE-125132 →	+0.593	+2.874	.013	.021	3	1
LARGE_INTESTINE	MetAP2 Inhibitor →	+0.303	+2.807	.021	.044	2	1
LARGE_INTESTINE	CP466722 →	+0.416	+2.874	.026	.021	1	1
LARGE_INTESTINE	Ispinesib Mesylate →	+0.715	+2.874	.020	.021	1	1
LARGE_INTESTINE	Torin 2 →	+0.682	+2.655	.010	.044	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

AT-7519 by PLA2G7 expression — LARGE_INTESTINE

Explore this box plot interactively →