PLA2G4F

Across TCGA patient cohorts, PLA2G4F mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G4F-associated genes across cancer lineages are EGFR_pY1068, NF2, and PCNA. Each is linked with PLA2G4F in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G4F-to-partner and partner-to-PLA2G4F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PLA2G4F-low versus PLA2G4F-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4F→partner) and Y-score (partner→PLA2G4F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.254	-2.000	.009	.030	3	2
UCEC	NF2 →	+0.265	+2.584	.001	.010	3	2
UCEC	PCNA →	+0.198	+1.584	.019	.036	3	2
UCEC	TFRC →	+0.624	+3.459	.002	.005	3	2
UCEC	4E-BP1 →	+0.310	+2.000	.003	.010	3	2
SKCM	Gab2 →	-0.454	-3.459	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

EGFR_pY1068 by PLA2G4F expression — UCEC

Explore this box plot interactively →