PLA2G4D

Across TCGA patient cohorts, PLA2G4D protein abundance is significantly associated with the RNA expression of many other genes, with 1,658 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PLA2G4D-associated genes across cancer lineages are TREX2, RNF225, and LGALS1. Each is linked with PLA2G4D in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G4D-to-partner and partner-to-PLA2G4D results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLA2G4D versus TREX2 in HNSC, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4D→partner) and Y-score (partner→PLA2G4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TREX2 →	+1.573	+1.155	<.001	<.001	3	2
UCEC	RNF225 →	+1.365	+0.714	<.001	.001	3	2
UCEC	LGALS1 →	+2.449	+0.770	.003	<.001	3	1
UCEC	POLR2F →	+1.197	+0.839	.003	<.001	3	1
UCEC	TSPO →	+4.395	+0.790	.005	<.001	3	1
UCEC	TAB1 →	+0.715	+0.710	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,658 associations by consensus.

PLA2G4D vs TREX2 — HNSC

Explore this scatter interactively →