PLA2G4D

Across TCGA patient cohorts, PLA2G4D mutation is significantly associated with the RNA expression of many other genes, with 3,156 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G4D-associated genes across cancer lineages are SPATA5L1, LONP1, and EIF2AK4. Each is linked with PLA2G4D in more than 2 cancer types. Because this analysis shows association rather than direction, both PLA2G4D-to-partner and partner-to-PLA2G4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA5L1 grouped by PLA2G4D-low versus PLA2G4D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4D→partner) and Y-score (partner→PLA2G4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPATA5L1 →	+0.468	+2.273	<.001	<.001	3	3
UCEC	LONP1 →	+0.678	+2.273	<.001	<.001	3	3
UCEC	EIF2AK4 →	+0.414	+2.928	<.001	<.001	3	3
UCEC	NARS1 →	+0.486	+2.263	<.001	<.001	3	3
READ	RNU7-19P →	+1.080	+5.925	<.001	.002	3	2
BRCA	TRDD1 →	+0.545	+7.057	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,156 associations by consensus.

SPATA5L1 by PLA2G4D expression — UCEC

Explore this box plot interactively →