PLA2G4D

Across TCGA patient cohorts, PLA2G4D mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G4D-associated genes across cancer lineages are Cyclin-B1, JNK_pT183_Y185, and p62 Lck ligand. Each is linked with PLA2G4D in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G4D-to-partner and partner-to-PLA2G4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PLA2G4D-low versus PLA2G4D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4D→partner) and Y-score (partner→PLA2G4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.649	+3.584	.001	.002	3	2
UCEC	JNK_pT183_Y185 →	-0.193	-2.308	.001	.001	3	2
UCEC	p62 Lck ligand →	+0.353	+3.009	.002	<.001	3	2
UCEC	Di-Ras3 →	-0.116	-2.308	.029	.033	3	2
SKCM	NDRG1_pT346 →	-0.546	-1.874	.021	.047	3	1
SKCM	PR →	-0.066	-1.584	.040	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Cyclin-B1 by PLA2G4D expression — UCEC

Explore this box plot interactively →