PLA2G4D

Across TCGA cell cohorts, PLA2G4D RNA expression is significantly associated with the go_rna of many other GO terms, with 1,587 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PLA2G4D-associated GO terms across cancer lineages are Epidermal growth factor receptor signaling pathway, Positive regulation of defense response to virus by host, and Negative regulation of RNA splicing. Each is linked with PLA2G4D in more than 6 cancer types. Because this analysis shows association rather than direction, both PLA2G4D-to-partner and partner-to-PLA2G4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epidermal growth factor receptor signaling pathway grouped by PLA2G4D-low versus PLA2G4D-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4D→partner) and Y-score (partner→PLA2G4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Epidermal growth factor receptor signaling pathway →	+0.104	+0.541	<.001	.001	3	7
PANCREAS	Positive regulation of defense response to virus by host →	+0.125	+0.501	<.001	<.001	3	6
PANCREAS	Negative regulation of RNA splicing →	+0.066	+0.276	<.001	.004	3	6
PANCREAS	Response to indole-3-methanol →	+0.186	+0.406	<.001	.001	3	6
PANCREAS	Cellular response to indole-3-methanol →	+0.192	+0.432	<.001	<.001	3	6
LUNG_NSCLC_LUSC	Signal transduction involved in regulation of gene expression →	+0.192	+0.140	.002	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,587 associations by consensus.

Epidermal growth factor receptor signaling pathway by PLA2G4D expression — URINARY_TRACT

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