PLA2G4D

Across TCGA cell cohorts, PLA2G4D mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLA2G4D-associated genes across cancer lineages are NPHS2, OR52L1, and SAXO1. Each is linked with PLA2G4D in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G4D-to-partner and partner-to-PLA2G4D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPHS2 grouped by PLA2G4D-low versus PLA2G4D-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G4D→partner) and Y-score (partner→PLA2G4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NPHS2 →	+0.187	+5.044	<.001	<.001	3	2
CNS	OR52L1 →	+0.033	+4.321	<.001	.009	3	2
BLOOD_Leukemia	SAXO1 →	+0.033	+3.518	.005	.008	3	2
BLOOD_Leukemia	KRTAP10-3 →	+0.063	+3.890	<.001	<.001	3	2
URINARY_TRACT	NOBOX →	+0.020	+5.044	<.001	<.001	3	1
URINARY_TRACT	CLEC14A →	+0.013	+4.217	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

NPHS2 by PLA2G4D expression — URINARY_TRACT

Explore this box plot interactively →