Across TCGA cell cohorts, PLA2G2E mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLA2G2E-associated genes across cancer lineages are GFRA4, NLGN4Y, and FOXI2. Each is linked with PLA2G2E in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G2E-to-partner and partner-to-PLA2G2E results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G2E→partner) and Y-score (partner→PLA2G2E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GFRA4 →	+0.030	+3.930	<.001	.003	3	1
LARGE_INTESTINE	NLGN4Y →	+0.117	+4.000	<.001	.004	3	1
LARGE_INTESTINE	FOXI2 →	+0.019	+4.217	<.001	.001	3	1
LARGE_INTESTINE	FAM170A →	+0.123	+4.070	<.001	.003	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

PLA2G2E survival (RNA) · tumor vs normal (RNA) · all PLA2G2E data types