PLA2G15

Across TCGA pan-cancer cohorts, PLA2G15 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PLA2G15’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PLA2G15 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PLA2G15 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

HNSC, LUAD, and PDAC are the cancer types where PLA2G15 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLA2G15 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.313	<.001	8	view →
LUAD	Male	All	−0.373	<.001	7	view →
PDAC	Female	All	+0.608	<.001	6	view →
LSCC	Male	II,III,IV	−0.498	<.001	6	view →
CCRCC	Male	III,IV	−0.291	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PLA2G15–HNSC

Open the HNSC breakdown →