PLA2G15

Across TCGA cell cohorts, PLA2G15 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLA2G15-associated genes across cancer lineages are WFDC12, DEFB4A, and TRIM49B. Each is linked with PLA2G15 in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G15-to-partner and partner-to-PLA2G15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC12 grouped by PLA2G15-low versus PLA2G15-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G15→partner) and Y-score (partner→PLA2G15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	WFDC12 →	+0.198	+3.874	<.001	.005	3	1
BLOOD_Leukemia	DEFB4A →	+0.096	+4.269	.001	.002	3	1
BLOOD_Leukemia	TRIM49B →	+0.111	+3.874	<.001	.005	3	1
LARGE_INTESTINE	CPLX4 →	+0.041	+3.807	<.001	.001	3	1
LARGE_INTESTINE	OR1L6 →	+0.018	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PPIAL4G →	+0.015	+4.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

WFDC12 by PLA2G15 expression — BLOOD_Leukemia

Explore this box plot interactively →