PLA2G12A

Across TCGA patient cohorts, PLA2G12A mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA2G12A-associated genes across cancer lineages are RN7SKP181, MTCO2P17, and MTCO2P15. Each is linked with PLA2G12A in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA2G12A-to-partner and partner-to-PLA2G12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP181 grouped by PLA2G12A-low versus PLA2G12A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA2G12A→partner) and Y-score (partner→PLA2G12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP181 →	+0.146	+5.685	<.001	.003	3	2
CESC	MTCO2P17 →	+0.094	+5.010	.001	.009	3	1
CESC	MTCO2P15 →	+0.089	+5.969	<.001	.002	3	1
CESC	MIR3126 →	+0.741	+5.010	<.001	.009	3	1
CESC	RNU6-668P →	+0.426	+5.539	<.001	.004	3	1
CESC	RPL31P13 →	+0.154	+7.164	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

RN7SKP181 by PLA2G12A expression — BLCA

Explore this box plot interactively →