PLA2G10

Across TCGA pan-cancer cohorts, PLA2G10 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PLA2G10 data layer compared with 2 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher PLA2G10 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PLA2G10 expression acts as an unfavorable survival marker, although some lineages such as BRCA and KIRC show a favorable association.

BRCA, KIRC, and UCEC are the cancer types where PLA2G10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.978	0.946	<.001	105	view →
KIRC	DFS	Quartile	All	0.922	0.822	<.001	94	view →
UCEC	DFS	Median	All	0.744	0.544	<.001	66	view →
ACC	DFS	Median	All	0.373	0.776	<.001	58	view →
MESO	DFS	Median	II,III,IV	0.266	0.634	.006	44	view →
KIRP	DFS	Tertile	All	0.604	0.621	.006	34	view →
COAD	OS	Quartile	IV	0.902	0.366	.011	29	view →
ESCA	OS	Tertile	All	0.382	1.000	.002	27	view →
UVM	DFS	Tertile	III,IV	0.193	1.000	.013	18	view →
HNSC	OS	Tertile	All	0.284	0.564	.003	17	view →
GBM	DFS	Tertile	All	0.327	0.195	.007	15	view →
CHOL	OS	Median	II,III,IV	0.268	0.974	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PLA2G10–BRCA (OS)

Open the BRCA breakdown →