PLA1A

Across TCGA patient cohorts, PLA1A protein abundance is significantly associated with the RNA expression of many other genes, with 1,510 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PLA1A-associated genes across cancer lineages are WRAP53, ZNRF3, and ORAOV1P1. Each is linked with PLA1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA1A-to-partner and partner-to-PLA1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PLA1A versus WRAP53 in LUAD, with a Pearson correlation of -0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA1A→partner) and Y-score (partner→PLA1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	WRAP53 →	-0.611	-0.612	<.001	.001	3	2
CCRCC	ZNRF3 →	-0.666	-0.648	<.001	<.001	3	2
UCEC	ORAOV1P1 →	+2.135	+0.930	.004	.002	3	2
BRCA	HTR2B →	+1.386	+0.708	.002	.002	3	2
CCRCC	TRIM50 →	+0.493	+0.699	.003	.006	3	2
CCRCC	PTGIR →	+0.937	+0.559	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,510 associations by consensus.

PLA1A vs WRAP53 — LUAD

Explore this scatter interactively →