PLA1A

Across TCGA patient cohorts, PLA1A mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLA1A-associated genes across cancer lineages are 14-3-3_beta, JNK2, and Tuberin. Each is linked with PLA1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PLA1A-to-partner and partner-to-PLA1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PLA1A-low versus PLA1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLA1A→partner) and Y-score (partner→PLA1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.131	-3.295	.003	.009	3	2
UCEC	JNK2 →	+0.321	+3.179	<.001	.010	3	2
UCEC	Tuberin →	+0.371	+3.331	.002	.005	3	2
SKCM	mTOR →	+0.224	+3.321	.027	.009	3	1
SKCM	Rad50 →	+0.246	+2.459	.044	.017	3	1
SKCM	Smac →	+0.320	+2.239	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

14-3-3_beta by PLA1A expression — UCEC

Explore this box plot interactively →