Across TCGA pan-cancer cohorts, PKP3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PKP3 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PKP3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PKP3 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

UCEC, HNSC, and PRAD are the cancer types where PKP3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.225	0.772	<.001	12	view →
HNSC	OS	Median	IV	0.151	0.641	.005	12	view →
PRAD	DFS	Median	All	0.617	0.886	.013	6	view →
LIHC	OS	Median	All	0.015	0.784	<.001	6	view →
SKCM	OS	Median	II,III,IV	1.000	0.830	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: PKP3 tumor-vs-normal RNA expression · all PKP3 data types