Across TCGA patient cohorts, PKP3 protein abundance is significantly associated with the RNA expression of many other genes, with 14,682 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PKP3-associated genes across cancer lineages are FGF7, IGF1, and S100A14. Each is linked with PKP3 in more than 6 cancer types. Because this analysis shows association rather than direction, both PKP3-to-partner and partner-to-PKP3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKP3→partner) and Y-score (partner→PKP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FGF7 →	-1.205	-0.549	.002	.002	3	7
OV	IGF1 →	-0.865	-0.627	.002	<.001	3	7
OV	S100A14 →	+1.992	+0.745	<.001	<.001	3	7
OV	CARD8 →	-0.657	-0.757	.001	<.001	3	6
OV	CXCL12 →	-1.850	-0.669	<.001	.001	3	6
UCEC	GYPC →	-0.717	-0.296	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,682 associations by consensus.

Exploration

PKP3 survival (RNA) · tumor vs normal (RNA) · all PKP3 data types