Across TCGA patient cohorts, PKP3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKP3-associated genes across cancer lineages are HER3, JNK2, and N-Ras. Each is linked with PKP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKP3-to-partner and partner-to-PKP3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKP3→partner) and Y-score (partner→PKP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3 →	-0.258	-2.990	.044	.036	3	1
UCEC	JNK2 →	+0.220	+3.469	.017	.002	3	1
UCEC	N-Ras →	-0.145	-2.571	.008	.011	3	1
UCEC	p90 RSK →	+0.231	+1.887	.009	.031	2	2
UCEC	P-Cadherin →	-0.164	-2.999	.014	.035	3	1
UCEC	PDK1_pS241 →	+0.166	+3.026	.037	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

PKP3 survival (RNA) · tumor vs normal (RNA) · all PKP3 data types