PKP2

Across TCGA pan-cancer cohorts, PKP2 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PKP2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PKP2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PKP2 is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, LSCC, and LUAD are the cancer types where PKP2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PKP2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	II,III,IV	−0.708	<.001	11	view →
LSCC	Male	II,III,IV	+1.436	<.001	9	view →
LUAD	Male	All	+0.798	<.001	8	view →
HNSC	All	All	−0.298	.021	4	view →
OV	All	All	+1.359	.010	2	view →
PDAC	Female	All	−0.311	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PKP2–CCRCC

Open the CCRCC breakdown →