PKP1

Across TCGA pan-cancer cohorts, PKP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PKP1 data layer compared with 19 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PKP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PKP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and CCRCC are the cancer types where PKP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	1.000	0.577	.016	9	view →
HNSC	DFS	Tertile	II,III,IV	0.986	0.864	.005	8	view →
CCRCC	DFS	Median	II,III,IV	0.205	1.000	.010	6	view →
LUAD	DFS	Quartile	All	0.931	0.996	.012	4	view →
UCEC	OS	Quartile	All	1.000	0.804	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PKP1–LSCC (DFS)

Open the LSCC breakdown →