PKP1

Across TCGA patient cohorts, PKP1 protein abundance is significantly associated with the protein abundance of many other proteins, with 19,065 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PKP1-associated proteins across cancer lineages are PKP1_S142, PKP1_S185, and PKP1_S205. Each is linked with PKP1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PKP1-to-partner and partner-to-PKP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PKP1 versus PKP1_S142 in LSCC, with a Pearson correlation of 0.90.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PKP1→partner) and Y-score (partner→PKP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PKP1_S142 →	+2.501	+1.912	<.001	<.001	3	6
UCEC	PKP1_S185 →	+2.895	+1.523	<.001	<.001	3	6
LSCC	PKP1_S205 →	+2.500	+1.815	<.001	<.001	3	6
LSCC	PKP1_S191 →	+2.628	+1.696	<.001	<.001	3	5
LUAD	PKP1_S225 →	+2.507	+1.617	<.001	<.001	3	5
PDAC	PKP1_S237 →	+3.153	+2.040	.008	.004	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,065 associations by consensus.

PKP1 vs PKP1_S142 — LSCC

Explore this scatter interactively →