PKP1

Across TCGA patient cohorts, PKP1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKP1-associated genes across cancer lineages are 4E-BP1, A-Raf_pS299, and JNK2. Each is linked with PKP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PKP1-to-partner and partner-to-PKP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PKP1-low versus PKP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKP1→partner) and Y-score (partner→PKP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.295	+2.584	.002	.010	3	3
UCEC	A-Raf_pS299 →	-0.110	-2.000	.010	.030	3	2
UCEC	JNK2 →	+0.163	+1.594	.023	.042	3	2
UCEC	mTOR_pS2448 →	-0.150	-2.571	.005	.010	3	2
UCEC	p27_pT198 →	+0.087	+2.000	.024	.030	3	2
UCEC	Rab25 →	-0.334	-2.000	.005	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

4E-BP1 by PKP1 expression — UCEC

Explore this box plot interactively →