PKP1

Across TCGA cell cohorts, PKP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,765 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PKP1-associated GO terms across cancer lineages are Transepithelial water transport, Cellular respiration, and Ribonucleoside triphosphate biosynthetic process. Each is linked with PKP1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PKP1-to-partner and partner-to-PKP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transepithelial water transport grouped by PKP1-low versus PKP1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKP1→partner) and Y-score (partner→PKP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Transepithelial water transport →	+2.472	+6.871	<.001	<.001	3	10
PANCREAS	Cellular respiration →	+0.057	+1.321	.002	.001	3	8
BONE	Ribonucleoside triphosphate biosynthetic process →	+0.112	+4.579	.001	.003	3	7
PANCREAS	Regulation of syncytium formation by plasma membrane fusion →	+0.084	+0.877	.001	.001	2	8
BLOOD_Lymphoma	Negative regulation of RNA splicing →	+0.078	+0.056	<.001	<.001	3	7
BLOOD_Lymphoma	Regulation of nucleocytoplasmic transport →	+0.036	+0.045	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,765 associations by consensus.

Transepithelial water transport by PKP1 expression — BONE

Explore this box plot interactively →