PKNOX2

Across TCGA patient cohorts, PKNOX2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,359 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PKNOX2-associated genes across cancer lineages are FLRT3, TRPM4, and EPHA2. Each is linked with PKNOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKNOX2-to-partner and partner-to-PKNOX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PKNOX2 versus FLRT3 in GBM, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKNOX2→partner) and Y-score (partner→PKNOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FLRT3 →	+1.326	+0.599	.002	.001	3	2
GBM	TRPM4 →	-0.635	-0.671	.007	.002	3	2
GBM	EPHA2 →	-0.846	-0.658	.005	.001	3	2
GBM	ZNF385A →	-0.898	-0.644	.007	.004	3	2
LSCC	CRYBG2 →	-0.716	-0.349	.009	.001	3	2
GBM	ESS2 →	+0.280	+0.577	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,359 associations by consensus.

PKNOX2 vs FLRT3 — GBM

Explore this scatter interactively →