PKNOX2

Across TCGA patient cohorts, PKNOX2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKNOX2-associated genes across cancer lineages are Cyclin-B1, eIF4E, and FOXO3a_pS318_S321. Each is linked with PKNOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKNOX2-to-partner and partner-to-PKNOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by PKNOX2-low versus PKNOX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKNOX2→partner) and Y-score (partner→PKNOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.580	+2.321	.001	.005	3	2
UCEC	eIF4E →	+0.165	+3.472	.017	.002	3	2
UCEC	FOXO3a_pS318_S321 →	-0.083	-1.405	.043	.043	3	2
UCEC	GAPDH →	+0.468	+2.321	.008	.005	3	2
UCEC	mTOR_pS2448 →	-0.105	-1.986	.032	.029	3	2
UCEC	Notch1 →	+0.108	+2.013	.020	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Cyclin-B1 by PKNOX2 expression — UCEC

Explore this box plot interactively →