PKNOX2

Across TCGA cell cohorts, PKNOX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,308 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PKNOX2-associated GO terms across cancer lineages are Cellular response to macrophage colony-stimulating factor stimulus, tRNA transcription by RNA polymerase III, and Cardiac conduction. Each is linked with PKNOX2 in more than 6 cancer types. Because this analysis shows association rather than direction, both PKNOX2-to-partner and partner-to-PKNOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to macrophage colony-stimulating factor stimulus grouped by PKNOX2-low versus PKNOX2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKNOX2→partner) and Y-score (partner→PKNOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Cellular response to macrophage colony-stimulating factor stimulus →	-1.214	-2.123	<.001	<.001	3	7
SOFT_TISSUE	tRNA transcription by RNA polymerase III →	+0.123	+2.068	<.001	<.001	3	6
SKIN	Cardiac conduction →	-0.098	-1.441	.001	<.001	3	6
BONE	Regulation of matrix metallopeptidase secretion →	+0.208	+1.540	.001	<.001	3	5
SOFT_TISSUE	Peptidyl-amino acid modification →	+0.029	+1.663	.003	.008	3	5
SOFT_TISSUE	Regulatory ncRNA-mediated post-transcriptional gene silencing →	+0.065	+1.777	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,308 associations by consensus.

Cellular response to macrophage colony-stimulating factor stimulus by PKNOX2 expression — SOFT_TISSUE

Explore this box plot interactively →