PKNOX2

Across TCGA cell cohorts, PKNOX2 mutation is significantly associated with the mutation status of many other genes, with 3,861 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKNOX2-associated genes across cancer lineages are DMXL2, ZNF549, and ADGRB2. Each is linked with PKNOX2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PKNOX2-to-partner and partner-to-PKNOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMXL2 grouped by PKNOX2-low versus PKNOX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKNOX2→partner) and Y-score (partner→PKNOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DMXL2 →	+2.056	+3.450	<.001	<.001	1	5
BLOOD_Leukemia	ZNF549 →	+6.145	+5.479	<.001	<.001	1	4
CNS	ADGRB2 →	+4.044	+5.000	.008	.008	1	4
BLOOD_Leukemia	LRBA →	+2.560	+4.364	.002	.002	1	4
BLOOD_Leukemia	TENM3 →	+2.037	+3.830	.008	.008	1	4
LUNG_SCLC	NBEAL1 →	+4.502	+5.066	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,861 associations by consensus.

DMXL2 by PKNOX2 expression — LARGE_INTESTINE

Explore this box plot interactively →