PKNOX1

Across TCGA pan-cancer cohorts, PKNOX1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PKNOX1 data layer compared with 24 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PKNOX1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PKNOX1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC, LUSC, and UCEC are the cancer types where PKNOX1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.062	0.874	<.001	36	view →
LUSC	OS	Median	All	0.147	0.777	<.001	36	view →
UCEC	DFS	Median	All	1.000	0.626	.011	20	view →
ESCA	DFS	Median	II,III,IV	0.082	0.523	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PKNOX1–KIRC (OS)

Open the KIRC breakdown →