PKNOX1

Across TCGA patient cohorts, PKNOX1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,203 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PKNOX1-associated genes across cancer lineages are NCF2, PLEKHH2, and ZIK1. Each is linked with PKNOX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PKNOX1-to-partner and partner-to-PKNOX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PKNOX1 versus NCF2 in HNSC, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKNOX1→partner) and Y-score (partner→PKNOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NCF2 →	-0.659	-0.329	<.001	<.001	3	4
UCEC	PLEKHH2 →	+1.076	+0.169	<.001	.005	3	3
UCEC	ZIK1 →	+0.722	+0.202	<.001	.001	3	3
BRCA	MIR3671 →	+1.213	+0.288	<.001	<.001	3	3
CCRCC	GJC1 →	+0.745	+0.391	.005	.001	3	3
GBM	CD33 →	-0.650	-0.486	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,203 associations by consensus.

PKNOX1 vs NCF2 — HNSC

Explore this scatter interactively →