PKNOX1

Across TCGA cell cohorts, PKNOX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,949 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PKNOX1-associated GO terms across cancer lineages are Centrosome cycle, Signal transduction in response to DNA damage, and Positive regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with PKNOX1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PKNOX1-to-partner and partner-to-PKNOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Centrosome cycle grouped by PKNOX1-low versus PKNOX1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKNOX1→partner) and Y-score (partner→PKNOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Centrosome cycle →	+0.070	+0.582	<.001	<.001	3	13
BREAST	Signal transduction in response to DNA damage →	+0.072	+0.647	<.001	<.001	3	13
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.123	+0.632	<.001	<.001	3	12
BREAST	Negative regulation of chromosome organization →	+0.075	+0.521	.003	.003	3	12
LUNG_SCLC	Establishment of spindle orientation →	+0.142	+0.750	<.001	<.001	3	12
SOFT_TISSUE	Microtubule organizing center organization →	+0.089	+0.795	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,949 associations by consensus.

Centrosome cycle by PKNOX1 expression — BREAST

Explore this box plot interactively →