PKNOX1

Across TCGA cell cohorts, PKNOX1 mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PKNOX1-associated genes across cancer lineages are DMRTC1B, CWH43, and CUX2. Each is linked with PKNOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKNOX1-to-partner and partner-to-PKNOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMRTC1B grouped by PKNOX1-low versus PKNOX1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKNOX1→partner) and Y-score (partner→PKNOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DMRTC1B →	+0.064	+4.930	.001	.001	3	2
SKIN	CWH43 →	+0.046	+4.930	<.001	.001	3	1
SKIN	CUX2 →	+0.039	+4.095	<.001	.009	3	1
SKIN	IFNG →	+0.020	+5.022	<.001	.002	3	1
SKIN	OR4D1 →	+0.026	+4.467	.001	.004	3	1
SKIN	TMEM252 →	+0.058	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

DMRTC1B by PKNOX1 expression — SKIN

Explore this box plot interactively →