PKN3

Across TCGA pan-cancer cohorts, PKN3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PKN3 data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PKN3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PKN3 expression acts as an unfavorable survival marker.

LUAD, LSCC, and HNSC are the cancer types where PKN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.830	0.994	<.001	16	view →
LSCC	OS	Median	All	0.625	0.989	.044	4	view →
HNSC	DFS	Median	IV	0.338	0.748	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PKN3–LUAD (DFS)

Open the LUAD breakdown →