PKN2

Across TCGA patient cohorts, PKN2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,741 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PKN2-associated genes across cancer lineages are IGHV1-46, IGHV3-73, and DERL3. Each is linked with PKN2 in more than 5 cancer types. Because this analysis shows association rather than direction, both PKN2-to-partner and partner-to-PKN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PKN2 versus IGHV1-46 in HNSC, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKN2→partner) and Y-score (partner→PKN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IGHV1-46 →	-2.014	-0.228	<.001	<.001	3	6
HNSC	IGHV3-73 →	-2.275	-0.201	<.001	<.001	3	6
HNSC	DERL3 →	-0.671	-0.179	<.001	<.001	3	6
HNSC	RPF1 →	+0.443	+0.142	.006	.002	3	6
HNSC	CARMIL2 →	-0.606	-0.207	<.001	<.001	3	5
CCRCC	CXCR3 →	-0.778	-0.170	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,741 associations by consensus.

PKN2 vs IGHV1-46 — HNSC

Explore this scatter interactively →