PKN2

Across TCGA cell cohorts, PKN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,560 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PKN2-associated GO terms across cancer lineages are Positive regulation of centriole replication, Termination of RNA polymerase II transcription, and Nuclear pore complex assembly. Each is linked with PKN2 in more than 15 cancer types. Because this analysis shows association rather than direction, both PKN2-to-partner and partner-to-PKN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of centriole replication grouped by PKN2-low versus PKN2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKN2→partner) and Y-score (partner→PKN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Positive regulation of centriole replication →	+0.136	+1.167	<.001	<.001	3	16
KIDNEY	Termination of RNA polymerase II transcription →	+0.115	+0.961	.003	<.001	3	16
BLOOD_Lymphoma	Nuclear pore complex assembly →	+0.123	+0.954	<.001	<.001	3	15
SOFT_TISSUE	R-loop processing →	+0.074	+0.604	<.001	<.001	3	14
LUNG_SCLC	Regulation of centrosome duplication →	+0.104	+0.770	<.001	<.001	3	14
BLOOD_Myeloma	Positive regulation of organelle assembly →	+0.081	+1.078	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,560 associations by consensus.

Positive regulation of centriole replication by PKN2 expression — BLOOD_Myeloma

Explore this box plot interactively →