PKN2

Across TCGA cell cohorts, PKN2 mutation is significantly associated with the RNA expression of many other genes, with 721 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKN2-associated genes across cancer lineages are ZPBP2, CCER1, and PRAMEF15. Each is linked with PKN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKN2-to-partner and partner-to-PKN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZPBP2 grouped by PKN2-low versus PKN2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKN2→partner) and Y-score (partner→PKN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZPBP2 →	+0.089	+5.754	<.001	.002	3	1
CNS	CCER1 →	+0.016	+5.754	<.001	.002	3	1
CNS	PRAMEF15 →	+0.345	+4.981	<.001	.008	3	1
CNS	LEUTX →	+0.223	+5.321	<.001	.005	3	1
CNS	CELA3B →	+0.182	+5.754	<.001	.002	3	1
CNS	PRAMEF5 →	+0.459	+5.754	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 721 associations by consensus.

ZPBP2 by PKN2 expression — CNS

Explore this box plot interactively →