PKN2-AS1

Across TCGA pan-cancer cohorts, PKN2-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PKN2-AS1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher PKN2-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PKN2-AS1 expression acts as an unfavorable survival marker, although some lineages such as LAML and LIHC show a favorable association.

LGG, KICH, and ACC are the cancer types where PKN2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.346	0.540	<.001	53	view →
KICH	OS	Median	III,IV	0.309	0.906	.003	31	view →
ACC	DFS	Median	II,III,IV	0.534	0.880	.004	25	view →
BRCA	DFS	Tertile	IV	0.277	0.904	.003	23	view →
LAML	DFS	Median	All	0.473	0.264	.007	22	view →
PAAD	OS	Median	All	0.308	0.645	.002	22	view →
READ	OS	Tertile	III,IV	0.659	0.976	.011	21	view →
THCA	DFS	Tertile	IV	0.434	0.838	.005	19	view →
LIHC	OS	Median	II,III,IV	0.804	0.632	.003	19	view →
TGCT	DFS	Median	All	0.938	0.736	.001	18	view →
MESO	DFS	Median	All	0.306	0.461	.012	17	view →
CESC	OS	Median	All	0.485	0.686	.011	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PKN2-AS1–LGG (OS)

Open the LGG breakdown →