PKMP4

Across TCGA pan-cancer cohorts, PKMP4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PKMP4 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher PKMP4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PKMP4 expression acts as an unfavorable survival marker, although some lineages such as UCS and CESC show a favorable association.

UVM, LIHC, and OV are the cancer types where PKMP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	All	0.654	0.909	<.001	100	view →
LIHC	OS	Tertile	All	0.513	0.737	<.001	81	view →
OV	OS	Quartile	All	0.619	0.711	.010	30	view →
READ	OS	Median	II,III,IV	0.686	0.953	.004	30	view →
UCS	OS	Median	IV	0.844	0.234	.005	24	view →
THYM	DFS	Tertile	II,III,IV	0.654	0.949	.001	24	view →
CESC	OS	Median	II,III,IV	0.668	0.347	.002	22	view →
PAAD	OS	Tertile	All	0.505	0.668	.015	17	view →
COAD	OS	Median	IV	0.332	0.592	.015	15	view →
SKCM	OS	Quartile	III,IV	0.816	0.414	<.001	12	view →
BLCA	OS	Tertile	All	0.630	0.781	.010	11	view →
LUSC	DFS	Quartile	All	0.704	0.565	.028	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PKMP4–UVM (OS)

Open the UVM breakdown →