Q-omics provides the consensus-scored PKMP3 profile across patient tissues and cancer cell-line models. PKMP3 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, PKMP3 is differentially expressed in 16, with the highest sampling consensus in KICH. Additionally, PKMP3 RNA expression shows 19,450 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight MESO, KICH, and THYM as cancer lineages where PKMP3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PKMP3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PKMP3 survival associations across molecular data types. PKMP3 RNA expression shows survival associations in the most cancer types (26). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PKMP3 RNA expression–survival associations across cancer types. High PKMP3 expression shows favorable associations in MESO, LGG, PAAD, HNSC, ACC and KIRC. The MESO Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .006). Together, the overview and detailed table identify MESO as the clearest survival context for PKMP3 RNA expression.
This table summarizes PKMP3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for PKMP3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PKMP3 shows lower tumor expression in KICH, BLCA, THCA, LUSC, LUAD and UCEC. The KICH box plot shows higher PKMP3 RNA expression in normal versus tumor tissue (log2 FC = −1.689, t-test p < 0.001).
This table shows molecular features associated with PKMP3 in patient tissues and cancer cell lines. In patient samples, PKMP3 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
