PKMP1

Across TCGA patient cohorts, PKMP1 mutation is significantly associated with the RNA expression of many other genes, with 97 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PKMP1-associated genes across cancer lineages are RNU6-383P, RNU6-794P, and LINC02130. Each is linked with PKMP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKMP1-to-partner and partner-to-PKMP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-383P grouped by PKMP1-low versus PKMP1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKMP1→partner) and Y-score (partner→PKMP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-383P →	+1.201	+4.241	<.001	.003	3	2
LUAD	RNU6-794P →	+0.828	+4.995	<.001	<.001	3	2
UCEC	LINC02130 →	+0.470	+3.298	.008	.008	3	2
SKCM	RPL31P40 →	+0.049	+3.098	<.001	.008	3	2
UCEC	OR52I1 →	+0.088	+2.603	<.001	.007	3	2
SKCM	UQCRFS1P2 →	+0.032	+2.683	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

RNU6-383P by PKMP1 expression — LUAD

Explore this box plot interactively →