PKM

Across TCGA pan-cancer cohorts, PKM mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PKM data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PKM mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PKM expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, UCEC, and GBM are the cancer types where PKM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.402	0.890	<.001	51	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.329	.009	22	view →
GBM	OS	Quartile	All	0.280	0.619	.006	11	view →
PDAC	OS	Median	III,IV	0.634	0.875	.023	5	view →
CCRCC	OS	Quartile	II,III,IV	0.664	0.927	.028	3	view →
LSCC	DFS	Median	III,IV	0.481	0.811	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PKM–LUAD (OS)

Open the LUAD breakdown →