PKM

Across TCGA patient cohorts, PKM mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKM-associated genes across cancer lineages are ATM, Ku80, and Notch1. Each is linked with PKM in more than 2 cancer types. Because this analysis shows association rather than direction, both PKM-to-partner and partner-to-PKM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PKM-low versus PKM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKM→partner) and Y-score (partner→PKM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.660	-3.986	<.001	<.001	3	3
UCEC	Ku80 →	+0.267	+1.820	<.001	.002	3	2
UCEC	Notch1 →	+0.162	+1.807	<.001	.004	3	2
UCEC	P-Cadherin →	-0.147	-3.584	.002	.002	3	2
UCEC	PDCD4 →	-0.596	-2.807	<.001	.002	3	2
UCEC	Rab25 →	-0.325	-3.459	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

ATM by PKM expression — UCEC

Explore this box plot interactively →